Endocrine Abstracts

Introduction: Autophagy is a major clearance mechanism that destroys organelles and damaged proteins to keep cellular survival and homeostasis. Previous experimental studies have showed that autophagy has crucial role in the progression of diabetes and kidney diseases.Aim: This pilot cross-sectional study aimed to investigate the association between serum concentrations of beclin-1, a key regulator of autophagy, and diabetic nephropathy.<p class="abs...

Background: High prevalence of thyroid disorders is more common in T1 compared to T2 Diabetes Mellitus due to the associated autoimmunity, with hypothyroidism being the most common disorder.Objectives: The aim of this study is to assess the prevalence of autoimmune thyroid dysfunction among T2 diabetic Egyptian females and to find the correlation between the metabolic syndrome components and autoimmune thyroid dysfunction.Methods: ...

Background: Diabetes mellitus, hypovitaminosis D, and non-alcoholic fatty liver disease (NAFLD) are common medical conditions that share some risk factors, one of which is obesity. Both NAFLD and vitamin D deficiency have been linked to the development of metabolic syndrome and type 2 diabetes. The aim of this study is to evaluate the level of serum 25-hydroxy vitamin D [25(OH)D] in type 2 obese diabetic Egyptian patients with variable degrees of hepatic steatosis.<p class...

Background and aim: The normal range of thyroid functions during pregnancy differs between ethnic groups. The aim of this work was to assess the thyroid functions in normal pregnant Egyptian females in order to establish a population-specific reference range. Thyroid peroxidase antibodies (TPO Abs) and thyroid volume were also assessed.Methods: The study included 150 normal pregnant Egyptian females (with no history suggestive of thyroid...